[33] This 4a/b mutation of NOS3 gene was found to be associated with MI, among subjects of Turkish descent. [34] Significant association of the 4a/b polymorphism with CAD and MI has been amply reported in several ethnic populations even after adjustment of traditional risk factors. [22], [33], [35], [36] On the other hand, a few groups have also reported lack of association of this SNP with CAD. [37]–[39]. This evidence concerns the gene NOS3 and coronary artery disorder.