[24] Other studies have also shown lower NOS3 mRNA and serum NOx levels in genotypes with ≥1, 786C alleles, [26] although contradictory results have also been published. [124] Apart from lower NOx concentrations [26], synergistic effect of NOS3 Glu298Asp and T786-C polymorphism has also been reported to be the cause of increased CAD risk among carriers of this SNP. [5]. This evidence concerns the gene NOS3 and coronary artery disorder.