RELN and bipolar disorder: For instance, DNA methylations or histone modifications in combination with GABAergic and glutamatergic gene promoters are proposed to be critical elements in the pathogenesis of schizophrenia and bipolar disorder as demonstrated by decreased protein levels of GABA-ergic neuronal markers (reelin, RELN and glutamic acid decarboxylase 67, GAD67) [20–23].