In a study analyzing mantle cell lymphoma growth caused by IL-22, Gelebart et al.[25] discovered that the gene promoter for IL-22Rα contained multiple binding sites for NF-κB, a transcription factor that when activated contributes to the pathogenesis and progressive loss of pancreatic β-cells by generating reactive oxygen species and promoting β-cell apoptosis. This evidence concerns the gene IL22 and mantle cell lymphoma.