Neither GH peak nor IGF-1 concentrations were correlated to serum ferritin and liver enzymes.29 TM patients with GHD and IGF-1 deficiency also had a significantly lower bone mineral density (BMD) T-score at the lumbar spine compared to patients with normal GH and IGF-1 levels.29 These data confirm the role of IGF-1 in the pathophysiology of osteoporosis in addition to prenatal and postnatal body growth.30–37. This evidence concerns the gene IGF1 and osteoporosis.