7 Hematogones typically have an even higher nucleocytoplasmic ratio than lymphoblasts, with more homogeneous chromatin and a complete absence of visible nucleoli. Hematogones can also express the CD10 antigen, but can be distinguished from blast cells of B ALL by other immunophenotypic features, being characterised by regular, orderly acquisition and loss of B-lineage antigens; they can also be distinguished from mature lymphocytes by their weak expression of CD45 and, sometimes, by the expression of CD34.7 This evidence concerns the gene CD34 and acute lymphoblastic leukemia.