CD4 and neoplasm: In general, CD4+ cell counts >200 cells/mm3 and low IPI scores are independent positive prognostic factors.10,14 In patients on effective cART (i.e. undetectable viral load, high CD4, low incidence of comorbidities), HIV-related scores are less important prognostic factors than lymphoma related features (i.e. histology, tumor burden, LDH, performance status).20 The prognosis of HIV-associated PBL remains poor.