The A-disintegrin and metalloprotease 12 (ADAM-12) is an Insulin–like Growth Factor Binding Protein Protease produced by the placenta, and results into another potential marker of preeclampsia and FGR when tested in the first trimester, but with a low predictive value and a detection rate ranging between 7,16% and 20% [38-40]. The gene discussed is ADAM12; the disease is preeclampsia.