KDM4A and cardiac hypertrophy: Although cardiac-specific Kdm4a deficient mice and transgenic mice which overexpress Kdm4a show no overt baseline phenotype (Zhang et al., 2011), when subjected to pressure overload, inactivation of Kdm4a attenuates hypertrophic response while Kdm4a overexpression enhances cardiac hypertrophy (Zhang et al., 2011).