Nkx2.5-Cre driven dual function loss of GLP and G9a (GLP-KO/G9a-KD) mice showed reduction of H3K9me2 level in CM and atrioventricular septal defects, but not in single either GLP or G9a function loss (Inagawa et al., 2013). Here, EHMT2 is linked to familial atrioventricular septal defect.