The transient blockade of IL-13 resulted in the generation of high-avidity CTLs in the iliac and genito-rectal nodes (which drain the FGT), which were not found in the control protocol without soluble IL-13Rα2: high-avidity CTLs were more protective, shown by greater protection following an intranasal challenge with gag-expressing influenza in the IL-13Rα2 group. Here, IL13RA2 is linked to influenza.