Remarkably, expression of Tlr6 and Tlr1, but not that of Tlr2, Tlr7, and Tlr8, are under epigenetic control, since blood-stage infections of P. chabaudi induce alterations of the DNA methylation status of the promoters of Tlr1 and Tlr6 genes (Al-Quraishy et al., 2013). Here, TLR1 is linked to infection.