In lethal P. chabaudi malaria, there occurs biphasic, two-wavy increase in serum IL-1β, TNFα, and IL-6 with the first wave peaking on day 1 p.i. and the second wave peaking at maximal parasitemia on day 8 p.i. (Wunderlich et al., 2012). The gene discussed is IL1B; the disease is malaria.