Besides, the study of Jacob et al. shows that the interpretation of SFRP4 levels demand a detailed evaluation of the patients: In patients with ovarian cancer the reduction in SFRP4 levels could cover the increase associated with the development of diabetes whereas in diabetic patients the increased SFRP4 levels could interfere with the effort to predict the outcome of a newly diagnosed tumor. The gene discussed is SFRP4; the disease is diabetes mellitus.