For example, EBV-LMP1 is involved in the transformation, proliferation, apoptosis, and differentiation of NPC cells, and has also exhibited a positive effect on tumor angiogenesis by directly up-regulating expression of vascular endothelial growth factor (VEGF) via the Stat 3 transcription factor [4]. This evidence concerns the gene PDLIM7 and nasopharyngeal carcinoma.