However, for the first time, this study shows that a MedDiet can counterbalance the negative effects of acute hyperglycemia on endothelial function, inflammation and oxidative stress, and can recover the protective action of GLP-1, not only on insulin secretion, but, more interestingly, also on endothelial function and inflammation in type 2 diabetes. Here, GLP1R is linked to type 2 diabetes mellitus.