SERPINE1 and Sepsis: Despite the prognostic value of hemostatic abnormalities in sepsis and the description of several hemostatic gene polymorphisms, only a few association studies sought to correlate these single nucleotide polymorphisms (SNPs) (mainly the factor V Leiden mutations and the 4G genotype in the promoter region of plasminogen activator inhibitor-1) with susceptibility to severe sepsis and disease severity [15-17].