TNFRSF1A and glaucoma: In human glaucoma, TNFR1 has been linked with the upregulation of pro-apoptotic proteins including BAX and CASP1 [37], and TNFR1 deficiency protected neuronal cell cultures from glutamate excitotoxicity [47], and increased RGC survival in a mouse model of optic nerve crush [11,37].