Most importantly, in depth understanding of Aβ-induced Tau-pathology in terms of identification of the exact molecular entity, exact molecular mechanism, and their respective contributions to and interrelation with associated pathological features (synaptic dysfunction, neurodegeneration, brain atrophy, inflammation) is absolutely required to define fine-tuned therapeutic strategies with a higher success in preventing or halting AD. The gene discussed is MAPT; the disease is Brain atrophy.