In our study, SDF-1 and CXCR7 was expressed in the ductal cells of pancreatic adenocarcinoma tissue; the expression rates of SDF-1 and CXCR7 were 45.3% and 51.6%, but the expressions of SDF-1 and CXCR7 were negative in normal pancreatic tissues. The gene discussed is CXCL12; the disease is pancreatic adenocarcinoma.