In the present case-control study, we aimed to investigate the role of common single nucleotide polymorphisms (SNPs) in genes involved in the TF pathway of coagulation (i.e., the F2, F3 (TF) F5, F7, F10, EPCR, and TFPI genes) on the susceptibility of breast cancer. The gene discussed is TFPI; the disease is breast carcinoma.