The combined association findings for the recurrent case-only variants were strengthened when ss825678885:G>T, a 5′-UTR variant in one isoform, and a non-synonymous variant in a different isoform was included in the analysis (P=0.0189) and this may indicate that disruption of the expression of SLC1A2 (discussed above) and/or the presence of missense variants in the N-terminal portion of the EAAT2 protein leads to increased susceptibility of developing BD and/or SZ. This evidence concerns the gene SLC1A2 and Behcet disease.