Dysregulation of EAAT2 is associated with several neurological diseases including amyotrophic lateral sclerosis,29 Alzheimer's disease, epilepsy, as well as several psychiatric diseases such as schizophrenia (SZ), depression30 and autism.31, 32 The SLC1A2 SNP rs3794087 was found to be associated with essential tremors in a GWAS study.33 However, this finding has not been consistently replicated.34, 35, 36, 37. This evidence concerns the gene SLC1A2 and early-onset autosomal dominant Alzheimer disease.