Previous in vivo studies have also confirmed the effect of SNN on NAFL and partially unraveled its underlying mechanisms, including improving leptin and insulin resistance, inhibiting transcription of liver X receptor α (LXR-α)-mediated sterol regulatory element binding protein-1c (SREBP-1c), and maturation of SREBP-1c independent of LXR-α [24-27]. Here, NR1H3 is linked to Insulin resistance.