After the sixth week, the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and its target genes, Nqo1 and Gstp1, decreased in the MCD diet-induced NASH model (P <0.05 vs. control) but increased in mice administered with SNN (P <0.05 vs. model) (Figure 4B). Here, NFE2L2 is linked to metabolic dysfunction-associated steatohepatitis.