CYP2C8 and breast cancer: In conclusion, increased EET levels in BC might be due to upregulation of CYP2C8, 2C9, and 2J2 and downregulation of sEH, and knockdown of CYP2C8, 2C9, and 2J2 and overexpression of sEH could partially attenuate the proliferation and migration of BC cells.