CYP2C8 and carcinoma of esophagus: Indeed, previous in vivo and in vitro studies, including ours, have shown that CYP2C8, 2C9, and 2JC promote cancer cell proliferation, migration, angiogenesis, survival and invasion in several types of cancer such as hepatocellular carcinoma, esophageal carcinoma, and malignant hematologic disease [5, 6, 17].