Both CYP2C8 and 2C9 are highly expressed in human malignant neoplasms, such as renal carcinoma, lung adenocarcinoma (but not lung squamous cell carcinoma), ductal breast carcinoma, colon adenocarcinoma, basal cell carcinoma, bladder transitional cell carcinoma, ovarian adenocarcinoma, endometrial carcinoma, and prostate adenocarcinoma. Here, CYP2C8 is linked to cancer.