This implies that repressive forces like SAFA–PRC complexes rather than the lack of active forces like p53 may control PANDA and CDKN1A expression in these tumours, which is in line with published results for EZH2-dependent repression of CDKN1A in melanomas33 (Supplementary Fig. 7f and Supplementary Table 1). Here, EZH2 is linked to neoplasm.