Of note, we detected a significant negative correlation between PANDA, CDKN1A and SAFA, BMI1, EZH2 transcript levels in human hepatocellular carcinomas (HCC) when compared with normal liver samples with PANDA and CDKN1A levels significantly reduced (~2-fold) and SAFA (~2-fold), BMI1 (~1.7-fold) and EZH2 (~4.5-fold) levels significantly increased. This evidence concerns the gene EZH2 and hepatocellular carcinoma.