Of note, we detected a significant negative correlation between PANDA, CDKN1A and SAFA, BMI1, EZH2 transcript levels in human hepatocellular carcinomas (HCC) when compared with normal liver samples with PANDA and CDKN1A levels significantly reduced (~2-fold) and SAFA (~2-fold), BMI1 (~1.7-fold) and EZH2 (~4.5-fold) levels significantly increased. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.