MAPT and argyrophilic grain disease: It has been shown that the intracerebral injection of brain homogenates from human 4R tauopathies (AGD, progressive supranuclear palsy, and corticobasal degeneration) into mice transgenic for one isoform of wild-type 4R human Tau seeded the formation of pathological inclusions like those seen in the human tauopathies (37).