SFRP1 and colorectal carcinoma: In this study, we aim to examine the protein expression and methylation patterns of myofibroblast-derived SFRP1 in NAT and CRC tissues, and to demonstrate the effect of SFRP1 protein on HCT116 CRC cell line as a potential model of paracrine (stromal) inhibition of the Wnt pathway in colorectal carcinoma.