TP53 and acute myeloid leukemia: We have not observed the association between specific chromosomal abnormalities and MDM4 overexpression because we only have 15 CK-AML patients with wild-type TP53. Although it is not well known if there is a causal relationship between MDM4 overexpression and aneuploidy, these date raise the possibility that MDM4 overexpression plays a role in CK-AML pathogenesis.