Our results showed that WISP1 SNPs (rs2929965, rs2929969, rs2929970, rs2929973, rs754958) contributed to the overall toxicity in different subgroups; WISP1 SNPs (rs16904853, rs2929970, rs2977549, rs2977551) were related to hematologic toxicity, and WISP1 SNPs (rs2929946, rs2929970, rs2977519, rs2977536, rs3739262, rs754958) were related to the gastrointestinal toxicity of platinum-based chemotherapy in lung cancer patients. This evidence concerns the gene CCN4 and lung cancer.