KMT2B and Kleefstra syndrome: Hence, it can be proposed that KMT2B could also be a part of the chromatin modification module proposed by Kleefstra et al. [12], along with KMT2C, SMARCB1 and NR1I3, MBD5 and EHMT1. It is remarkable that the Kleefstra syndrome-like phenotype could be the result of recessive variant identified in family MRQ14 (Figure 1A), whereas all other previously reported gene mutations associated with KS are dominantly inherited.