KMT2D and Respiratory tract infection: Kleefstra et al. [8], reported a de novo mutation in KMT2C to cause dominant ID, similarly 41 likely pathogenic mutations in KMT2D gene causing Kabuki syndrome (MIM 147920) have been reported in 86 patients, having dysmorphic facial features, bone deformities, hypotonia, congenital heart defects, ID, urinary tract and respiratory tract infections [20].