The increase of c-Fos expression in the VLPAG and to a lesser extent in the RVM of SAL-treated ARTH animals indicates an overall increase in the tonic activity of the PAG-RVM-spinal cord pathways after the induction of experimental monoarthritis, which is in accordance with the enhancement of descending inhibitory circuits during chronic inflammation [74]–[77]. The gene discussed is FOS; the disease is inflammatory response.