CDKN1A and hepatocellular carcinoma: In HCC cells it was documented that overexpression of AEG-1 or SND1 resulted in decreased expression of several tumor suppressor genes that are targets of oncomiRNAs, e.g., PTEN, target of miR-221 and miR-21; CDKN1C (p57), target of miR-221; CDKN1A (p21), target of miR-106b; SPRY2, target of miR-21; and TGFBR2, target of miR-93 (12).