Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren’s syndrome, systemic sclerosis, myositis and multiple sclerosis patients have circulating blood cells with elevated levels of RNA from IFN-induced genes, i.e. an ‘IFN signature’ [1]–[3]. This evidence concerns the gene IFNA1 and Sjogren syndrome.