Systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjogren’s syndrome, systemic sclerosis, myositis and multiple sclerosis patients have circulating blood cells with elevated levels of RNA from IFN-induced genes, i.e. an ‘IFN signature’ [1]–[3]. The gene discussed is IFNA1; the disease is myositis disease.