In our study, the C-C chemokine CCL19 was used to activate its receptor CCR7, and the JAK2/STAT3 was also phosphorylated, which can be blocked by CCR7 mAb, suggesting that JAK2/STAT3 is a downstream signal pathway of CCR7 in SCCHN. Here, CCR7 is linked to head and neck squamous cell carcinoma.