In our research, the phosphorylation of STAT3 was reduced by Src and Pyk2 inhibitors and did not respond to PI3K inhibitor, suggesting that CCR7 activates STAT3 via Src and pyk2 in SCCHN, and PI3K/Akt does not participate in this STAT3 activation. The gene discussed is STAT3; the disease is head and neck squamous cell carcinoma.