Among an extensive group of proinflammatory cytokines studied, we found that elevations in CCL2, IL-1β, IL-6, IL8, IL-12 and TNFα were associated with acute SCLS episodes, and CXCL10 levels were both constitutively and acutely increased in SCLS sera. The gene discussed is IL1B; the disease is Systemic capillary leak syndrome.