At a 22-month off-therapy visit, she was found to have relapsed ALL, and she began reinduction chemotherapy per protocol COG-AALL0433, which included prednisone 13.3 mg/m2/dose TID × 28 days, as well as intermittent vincristine, doxorubicin, PEG-asparaginase 2500 units/m2, and intrathecal cytarabine and methotrexate. The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.