These include (i) older age at presentation, (ii) dominant cutaneous involvement in the absence of demonstrable involvement of bone marrow, (iii) lack of significant peripheral lymphadenopathy, and (iv) ALK negative, intense, and Golgi zone CD30 positivity in >75% tumor cells (in contrast to focal positivity in PTCL-NOS) [7]. Here, TNFRSF8 is linked to neoplasm.