Several biochemical parameters such as raised β2 microglobulin (>2200 mcg/L), CA-125 (>35 IU/L), ferritin, fasting triglyceride, and lactate dehydrogenase and reduced fibrinogen have been reported to be significantly (P < 0.001) associated with HLH subgroups of T-NHL and have been suggested to be important biomarkers of T-NHL associated HLH [4, 11–13]. The gene discussed is HLA-G; the disease is hemophagocytic syndrome.