PLAT and intracerebral hemorrhage: In this trial, patients with acute middle cerebral artery occlusions that were randomized to the combination of intravenous thrombolysis with 2-h continuous transcranial Doppler monitoring were found to achieve higher rates of recanalization within 2 h of treatment (without having higher rates of symptomatic intracerebral hemorrhage) when compared to patients treated only with intravenous tPA (8).