Besides cytokine overexpression, viral proteins, mainly Tat, stimulate cyclooxygenase-2 (COX-2)—an enzyme produced in response to TNF-α during inflammation, associated with decrease of ZO-1 expression in the tight junctions, which leads to BBB rupture and various neurological disorders (Wang et al., 2008; Strazza et al., 2011). This evidence concerns the gene PTGS2 and nervous system disorder.