In addition, this panel is targeting “hotspot” region of genes that are frequently mutated in human cancer thus other infrequently altered genes but of significance to serous ovarian cancers might have been excluded such as ARID1A, BRCA1, BRCA2, CSMD3, NF1, CDK12, FAT3 and GABRA6[30]. This evidence concerns the gene BRCA2 and cancer.