Among all the 87 advanced GIST patients, 45 (including 33 c-kit mutant GISTs, 5 wild-type GISTs, and 7 GISTs with unknown mutation type) were treated with IM, and the other 42 didn’t undergo any TKI therapy (10 due to personal reasons and the rest were cases prior to 2005). The gene discussed is KIT; the disease is gastrointestinal stromal tumor.