It is one of the TGF-β family ligands that bind to TFG-β type II receptor from outside the cell to initiate the well-known TGF-β signaling pathway, which is involved in tumor suppression through apoptosis but paradoxically also modulates cell proliferation, cell invasion, and immune regulation that tumor cells can take advantage of33. The gene discussed is TGFB1; the disease is neoplasm.