TP53 and cancer: Indeed, we found that the target genes are significantly enriched for meaningful cancer-related processes or pathways such as regulation of endothelial cell proliferation (GO:0001936; p < 3.09 × 10−04), p53 binding (GO:0002039; p < 0.0022), TGF-β signalling pathways (hsa04350; p < 0.01), regulation of EMT (GO:0010717; p < 0.0011), and pathways in cancers (hsa05200; p < 0.0058) (Supplementary Table S2).