PYCARD and neoplasm: All of these genes are known to be involved in different aspects of breast carcinogenesis, which includes tumor suppression, HIC1[26], CDH1[27], CDH13[28], CDKN2[29], DNA repair, MGMT[30], apoptosis, PYCARD[31], TNFRSF10C[32], and cell cycle regulation, CCNA1[33].