BRCA1 and breast carcinoma: On the other hand, 5 genes were differentially expressed with significant difference between the breast cancer patients and carriers, BRCA1 (p = 0.03), BIRC5 (p = 0.035), CCND2 (p0.034), ATM (p = 0.012) and IGF1R (p = 0.025) (Figure 4B).