As illustrated in Fig. 3m (and Supplementary Fig. 5c), we find that the MNK-dependent eIF4E1 protein level was consistent in two other B-lymphoid origin cell lines; however, in T-leukaemia (Jurkat) and colorectal carcinoma (HCT116) cells, the reduction in MNK level did not affect the eIF4E1 levels. The gene discussed is ATP7A; the disease is colorectal carcinoma.