MAPK1 and diffuse large B-cell lymphoma: We find that MEK inhibition (using AZD6244), which reduced ERK phosphorylation, had no impact on MNK kinase activity in DLBCL, evidenced by no change in eIF4E1-S209 phosphorylation at any time point tested, ranging from 45 min to 72 h (Fig. 2a and Supplementary Figs 1a,2).