To understand eIF4E1 and eIF4E3 modulation by MNK in DLBCL, we established stable cell lines of HLY-1 (ABC-DLBCL) and Pfeiffer (GCB-DLBCL) expressing wild-type and mutant eIF4E1, eIF4E3 and MNKs. This evidence concerns the gene EIF4E3 and diffuse large B-cell lymphoma.