In addition, higher MBL and ficolin-2 levels were observed in SSc patients with a reduced FVC <70% (median MBL levels 2.88 (1.66 to 4.45) vs. 0.85 (0.18 to 2.0), P = 0.001; mean ficolin-2 levels 0.73 (0.39) vs. 0.52 (0.32), P = 0.02). The gene discussed is MBL2; the disease is systemic sclerosis.