Apart from MBL, mean ficolin-2 levels were also significantly higher in diffuse SSc patients compared to limited and sine scleroderma SSc patients (0.71 (0.38) vs. 0.51 (0.32), P = 0.02), in line with a more frequent detection of the FCN2 wild-type haplotype GGAACG (−986G > A, −602G > A, −557A > G, −4A > G +6359 C > T and +6424 G > T) in diffuse SSc patients (51% vs. 30%, P = 0.03). The gene discussed is MBL2; the disease is scleroderma.