The single pathway exclusively enriched in context of ATRA effect on SHR was Ethanol degradation (Benjamini-Hochberg (B-H) p = 6.88 × 10-3, including SHR-exclusive downregulation of Aldh3a1), the remaining three pathways were overrepresented only in context of ATRA effect on SHR-Lx: D-myo-inostitol (1,4,5)-triphosphate degradation (B-H p = 1.83 × 10-3), Eicosanoid signaling (B-H p = 3.81 × 10-2) and Role of macrophages, fibroblasts and endothelial cells in rheumatoid arthritis (B-H p = 1.83 × 10-3 including upregulation of Il1b). The gene discussed is ALDH3A1; the disease is rheumatoid arthritis.