We have previously shown the Lx mutation present in the SHR-Lx congenic to result from 2.9 kb deletion of conserved noncoding element in Zbtb16 gene and to be responsible for polydactyly as well as left ventricle hypertrophy, hypertension and insulin resistance [12, 13, 20] and to sensitize towards ATRA-induced teratogenicity [10]. The gene discussed is ZBTB16; the disease is hypertensive disorder.