Since the only genetic difference between the two tested strains is confined to the chromosome 8 region harboring the seven abovementioned protein-coding genes, current data together with our previous results lead us to hypothesize that unique separation-of-function allele of Zbtb16 in SHR-Lx may be responsible for the observed transcriptome shifts resulting in ATRA-induced hyperlipidemia in the SHR-Lx congenic model. Here, ZBTB16 is linked to hyperlipidemia.