YB-1 was initially reported to interact with the Y-box element in the 5′ regulatory element of the HER2 gene [39], and nuclear YB-1 can trigger HER2 expression, which was confirmed by CHIP assay in gastric carcinoma cell lines MKN45, SNU216, and NCI-N87 [28,31,40]. The gene discussed is YBX1; the disease is gastric carcinoma.