MYC and medulloblastoma: To broadly identify genes that are essential for the survival of c-Myc-overexpressing MB cells, we performed a high-throughput siRNA screen targeting protein and lipid kinases in two clones of medulloblastoma DAOY cells: empty-vector-transfected (V11) or transfected with a c-Myc overexpressing construct (M2.1) [14] (Fig. 1A).