A study [30] in 76 AKI patients receiving renal support therapy (RST) demonstrated that the maximal ROC-AUC of renal prognosis prediction was 0.94 when combining various biomarkers (uHGF, uNGAL, uCystatin C, uNGAL/MMP-9, and uIL-18) at multiple time points. This evidence concerns the gene MMP9 and acute kidney injury.