C/EBPα expression levels in actinic keratoses and keratoacanthoma (precancerous skin conditions that can progress to SCC) were reduced relative to normal epidermis, and fully invasive SCCs expressed no detectable levels of C/EBPα, indicating a direct correlation between expression levels of C/EBPα and the severity of neoplasia [14]. This evidence concerns the gene CEBPA and neoplasm.