For this reason, we expressed chimeric proteins, consisting of the murine PrP N- and C-terminal signal peptides and the regions corresponding to the mature PrPs of ZebPrP-1, ZebPrP-2 and SauPrP-1, in a scrapie-infected mouse neuroblastoma cell line (22L-ScN2a). Here, SCN2A is linked to scrapie.