There was a significant association between tHcy and MetS (OR, 1.50; 95% CI, 1.16–1.93; P<0.001), and the result did not change appreciably when the models were additionally adjusted for age, sex, smoking, alcohol use, TC, LDL-C, ALT, UA, Cr, and eGFR (OR, 1.38; 95% CI, 1.02–1.88; P = 0.038). The gene discussed is GPT; the disease is metabolic syndrome.