To test this hypothesis we analyzed The Cancer Genome Atlas (TCGA) data for lung adenocarcinoma, tumors which exhibit frequent loss of Fhit expression and display the APOBEC signature, and determined that FHIT-low/APOBEC-high lung cancers exhibit the highest numbers of C > T and C > G mutations with the TC dinucleotide signature. Here, FHIT is linked to lung cancer.